Convergent synthesis of fully functionalized ring C allocolchicinoids. Benzannulation approach.

نویسندگان

  • A V Vorogushin
  • W D Wulff
  • H J Hansen
چکیده

[reaction: see text]. A novel convergent approach to fully functionalized ring C allocolchicinoids is developed which is based on the benzannulation reaction of Fischer carbene complexes with alkynes. The efficacy of this strategy was established with the conversion of bromide 1a (R1 = Me, R2 = H) to the biaryl phenol 3a (R = Me, R(L) = Pr, R(S) = H) via the carbene complex 2a. Bromide 1b (R1 = t-Bu, R2 = OMe) was then used for the analogous preparation of the diastereomeric allocolchicinoids 3b (R = Me, R(L) = Pr, R(S) = H).

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عنوان ژورنال:
  • Organic letters

دوره 3 17  شماره 

صفحات  -

تاریخ انتشار 2001